Journal article
Adverse metabolic phenotype of adolescent girls with non-alcoholic fatty liver disease plus polycystic ovary syndrome compared with other girls and boys
OT Ayonrinde, LA Adams, DA Doherty, TA Mori, LJ Beilin, WH Oddy, M Hickey, DM Sloboda, JK Olynyk, R Hart
Journal of Gastroenterology and Hepatology Australia | Published : 2016
DOI: 10.1111/jgh.13241
Abstract
Background and Aims:: Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) share risk associations of adiposity and insulin resistance. We examined the impact of a PCOS diagnosis on the metabolic phenotype of adolescent girls with NAFLD and compared this to girls without PCOS or NAFLD and to age-matched boys. Methods:: Community-based adolescents from the Raine Cohort participated in assessments for NAFLD (572 girls and 592 boys) and PCOS (244 girls). One hundred and ninety-nine girls attended both assessments. Results:: Amongst the 199 girls, PCOS was diagnosed in 16.1% and NAFLD in 18.6%. NAFLD was diagnosed in 10.1% of the boys. NAFLD was more prevalent in girls ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council [project grants (403968, 634445, 353514, 403981, and 634445), a postgraduate scholarship to Oyekoya T. Ayonrinde (404166), National Health and Medical Research Council Practitioner Fellowships to Martha Hickey (1058935) and to John K. Olynyk (1042370) and a research fellowship to Trevor A. Mori, the Gastroenterology Society of Australia (Astra Zeneca Career Development Award to Leon A. Adams), the Fremantle Hospital Medical Research Foundation (medical research grant), and a University of Western Australia Ada Bartholomew grant.